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The program was organized around the following topics: Protein structure and interactions. Mechanisms of cleavage, methylation, and sequence-recognition. Protein engineering: changing catalytic properties and specificity. Accessory activities: Control-proteins, Vsr-proteins, ATPase/translocases Epigenetics in animals and plants; bacterial methylomes Alternative DNA-modifications: hmC, 5fC, 5CaC, phosphorothioate Genetics of R-M systems: variety, evolution, relationships R-M systems in vivo: multiplicity, distribution, regulation Bioinformatics of R-M systems Gene Targeting reagents: Zinc fingers, meganucleases, TALENs, Cas9 Technologies: optical mapping, DNA-amplification, single-molecules