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The International Society for Antiviral Research (ISAR) sponsors an annual international meeting, the International Conference on Antiviral Research (ICAR). The 31st ICAR was held at the Alfândega Conference Center in Porto, Portugal, from June 11–15, 2018. As in previous years (Andrei et al., 2017; Vere Hodge, 2013, 2014, 2015, 2017), the meeting provided an interdisciplinary forum at which investigators involved in basic, translational, and clinical research worldwide met to review re- cent developments in all areas of antiviral research, drug and vaccine development. The overarching goal of the conference is to drive the discovery of new antiviral therapies by fostering collaboration among scientists from the fields of basic virology, medicinal chemistry, phar- macology, animal models of disease and toxicology in academia and the pharmaceutical industry.