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HPLC 2015 — The 42nd International Symposium on High Performance Liquid Phase Separations and Related Techniques — will be held from 21–25 June at the International Conference Center (CICG) in Geneva, Switzerland, hosted by the Division Analytical Sciences of the Swiss Chemical Society. Separation science, and liquid chromatography (LC) in particular, plays a key role in a number of fields including environmental science food science, systems biology, medicine, bioanalysis, and quality control. Exciting new developments in hardware and fundamentals, miniaturization, multidimensional separations, sample preparation, and mass spectrometric (MS) detection have become key topics in the field. To cover all of these aspects, the conference will be organized around three main parallel sessions covering: 1) Core Separation Technology: Understanding the Fundamentals to Drive Innovation; 2) Hyphenated and Multidimensional Separations: Multidimensional LC, Mass Spectrometry, and Related Detection Methods; and 3) High Impact Sample Preparation Separation and Detection: On the Edge of Current and Future Applications. A fourth session will be dedicated to tutorials and short oral contributions (5 min) from selected posters.