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The 2019 Gordon Research Conference (GRC) on the Biology of Aging will be held at the Grand Summit Hotel at Sunday River in Newry, Maine, on July 14-19, 2019. This will be the fifteenth Biology of Aging meeting since its origin in 1962. While geriatrics and gerontology societies and their conferences have focused on the medical, social, and psychological consequences of aging, in the most recent two decades there has been an explosion of knowledge on underlying mechanisms of the aging process. While the biology of aging is still a relatively new field, this GRC has become the premier forum for unpublished data presentation and discussions, resulting in a meeting where one can view exciting current science and also see the future directions of the field. This meeting is unique in its diversity, reflected in the theme of the 2019 conference: “Molecular, cellular, and physiological determinants of lifespan and healthspan”. Participating scientists will present basic studies in organisms ranging from invertebrates to humans. Appropriately, the talks and posters will reflect the diversity of the biology of aging by ranging from molecular studies to understanding how aging impacts numerous cellular and organ systems and organisms. We will also hear exciting work on interventions to modulate aging. Finally, this meeting will emphasize novel methods in metabolism, imaging and single cell efforts, which will stimulate the field.