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The goal of the first Workshop on the Next Generation of AstroParticle Experiments in Space (NextGAPES-2019) is to start the discussion of feasibility and layouts of new experiments designed to address scientific challenges of the 21st century and to build upon an extraordinary success of the high impact missions, such as ATIC, BESS, CREAM, PAMELA, AMS-02, Fermi-LAT, NUCLEON, CALET, DAMPE, ISS-CREAM… The scope of the meeting includes advances in astrophysics of cosmic rays up to the knee and above, gamma-ray astronomy, search for signatures of dark matter, and other challenges with emphasis on space-borne heavy multi-ton detectors that provide considerable gains in accuracy and sensitivity. Upon conclusion of the workshop we plan to prepare a white paper for the Committee of Space Research of the Russian Academy of Sciences for inclusion a heavy detector payload into the Russian Space Research Program. The workshop agenda includes an update on the current state and milestones of the development of the super-heavy launcher from a high-ranking representative of the Russian Space Agency (Roscosmos), and presentations of participants outlining the design, technology, requirements, and scientific goals of the next generation of space experiments.