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Key objectives of the EUPLAN initiative Translation of platelet genomics and proteomics knowledge into platelet function research in relation to thrombosis and bleeding. Identification and test of novel anti-platelet agents with high potential to prevent arterial thrombosis without side effect of bleeding. Establishment of the regulation of megakaryocytopoiesis and platelet production Characterization of new platelet mutations or genes throughout Europe that contribute to hemostasis and may lead to congenital bleeding disorders. Validation of system biology approaches to investigate platelet function. Development of new tests for the assessment of platelet function and for monitoring parameters of platelet functionality in the course of anti-thrombotic therapies. Integrated research to initiate clinical studies to test new anti-platelet medication.