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The UN is marking its 75th anniversary at a time of great disruption for the world, compounded by an unprecedented global health crisis with severe economic and social impacts. The ongoing Covid-19 pandemic is a stark reminder of the need for cooperation across borders, sectors and generations. Our response will determine how fast the world recovers, whether we achieve the Sustainable Development Goals, and how well we handle pressing challenges: from the climate crisis to pandemics, inequalities, new forms of violence, the rapid changes in technology and the shifting demographics.