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The 16th ICP Conference was held in Cambridge, Massachusetts, from June 28 through July 2, 2016, and continued the long tradition of bringing together diverse groups of clinicians and researchers to advance the field of neuromonitoring. We are particularly pleased to have been joined by the Cerebral Autoregulation Research Network (CARNet), whose sixth annual meeting was co-hosted with the 2016 ICP Conference and thereby significantly expanded the breadth and richness of the meeting. The conference attracted over 300 attendees, including 81 trainees, from 28 countries across six continents. It featured 235 contributed presentations as well as 15 keynote lectures and panel discussions from leading experts in the fields of traumatic brain injury, neurocritical care informatics, cerebrovascular autoregulation, hydrocephalus, visual impairment and intracranial hypertension, spreading depolarizations, and craniosynostosis. The 61 papers contained in this volume represent a cross section of the work presented at the conference and provide a glimpse into the current state-of-the-art in neuromonitoring. They also serve as a reminder that many important questions in these domains remain to be resolved to the full benefit of patients with brain injuries and neurological disorders.