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The International Symposium on Inorganic Ring Systems (IRIS) is one of the leading international conferences in the fields of Main Group Chemistry, including Organometallic Chemistry and Inorganic Materials Chemistry. Normally, this conference takes place every three years, however, due to the unforeseen circumstances regarding the COVID-19 pandemic, the conference was delayed by one year. The IRIS16 will now take place in Graz (Austria) from July 24 – 29, 2022.