ИСТИНА

• Охват: Международная
• Даты проведения: 26-31 марта 2023
• Место проведения: Galveston, United States
• Организатор:
  Gordon Research Conference
• Число участников из МГУ: 1
• Веб-сайт: https://www.grc.org/multi-drug-efflux-systems-conference/2023/
• Описание конференции:

  The Multi-Drug Efflux Systems GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field. Multidrug efflux systems export a wide a variety of substrates from cells and consequently are capable of conferring resistance to a wide range of chemotherapeutic agents. Multidrug resistance caused by active drug efflux is one of the major clinical impediments in anti-cancer chemotherapy and treatment of infectious diseases. Multidrug exporters are ubiquitously expressed in prokaryotic and eukaryotic organisms where they regulate absorption, distribution and excretion of xenobiotics, and protect sanctuary tissues by regulating the drug permeability of the blood-brain, -placenta and -testis barriers. In addition to regulating pharmacokinetics, transporters are also major players in dictating tissue-responses to drugs, from pharmacological efficacy to toxicity. The recent threat of widespread drug-resistant bacteria raises the prospect of a world without effective new antimicrobials, where patients are left vulnerable to previously treatable infectious diseases, and where organ transplants are impossible. A more complete understanding of multidrug efflux systems, from their physiological and biochemical functions to their localization, expression, and regulation is of paramount importance for the design of more targeted and highly effective treatments with improved patient outcomes. This conference will highlight recent developments in transporter biology, in particular on the molecular basis and structural dynamics of substrate recognition and transport, the integration of new biophysical insights in our knowledge of these processes, and the establishment of predictive rules of efflux inhibition and avoidance that can aid artificial intelligence and machine learning to delineate drug efficacy and pharmacological targeting. Further emphasis will be on the regulation of efflux systems mediated by local and global regulators and the multilayered control to optimize gene expression in response to specific environmental cues. As our understanding of transporter actions advances, there is greater potential for developing more specific and potent drugs that inhibit, modulate, or evade the multifaceted efflux systems and capitalize on nanomedicines and novel drug delivery strategies.

• Добавил в систему: Назаров Павел Александрович

Доклады:

• 2023 Multidrug resistance pumps as a keystone of bacterial resistance (Стендовый)
• Авторы: Nazarov Pavel, Noskov Sergei, Bari Md Abdul, Vasilisa Raldugina, Karakozova Marina