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The rehabilitation success of patients with schizophrenia depends on the necessity of reassessment that should be done during the rehabilitation period. Gender plays a significant role within differentiated approach for schizophrenia patients. Objectives: gender specific factors in the value orientations of schizophrenia patients. Method: 111 patients diagnosed with F20XX according to ICD-10, 53 men and 68 women, aged 35 ± 9 with disease duration of 5.4 ± 4.5, underwent a formalized clinical interview where they chose close and rejected values (direct naming), compared the values among themselves (the hierarchy analysis method) and reported values that had changed after the illness. Chosen values were then divided into clusters: abstract, interpersonal communication, social strength and self-realization values. Results: Significant differences among men and women with schizophrenia were found in close value choices such as family (p <0.01), friendship (p <0.01), faith (p <0.01), freedom (p <0 ,1) categories. Conclusion: Men and women with schizophrenia are different in their value choices what can be considered/concluded/claimed as they have different goals for rehabilitation and social adaptation. Women with schizophrenia mostly focused on interpersonal communication, thus, they showed significantly higher score in “family values score” than men, who denied or did not support those clusters of values. Men were orientated towards abstract and religious values. Hence, it should be taken into consideration while setting the rehabilitation goals.