ИСТИНА

The results reported in the literature suggest that partitioning of chromosomes into so-called topologically associated domains (TADs) is directly related to the partitioning of the genome into active and repressive segments. The fractal globule model was believed to describe TADs structure [1], but no clear observation of distinct domains was observed yet. We perform computer simulation of a polymer chain folding composed of blocks of inactive units (mimicking non-acetylated reversibly associating units) interspaced by shorter blocks of active chromatin (mimicking acetylated non-associating units). We show that only usage of saturating interactions allows obtaining of contact maps similar to real Hi-C maps.