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The transformation of the social and economic space in the South East Asia in the process of the integration of the region into the global knowledge economy could have different forms: population and production concentration and deconcentration, development of linear, areal and complex elements of the territorial structures, and it is largely determined with the geographical nature of the countries and the region as a whole. Common problems are superconcentration of economic activity in overpopulated centers, poor transport access to peripheries and lack of national and global connectivity.3 examples of large scale spatial socio-economic processes are discussed here. In the Philippines – the most territorially disintegrated state in the world, - regional policy and improving of connectivity are the most essential territorial issues. In Indonesia urban sprawl and improvement of transportation leads to formation of urban corridors in Java. In the Malacca Strait zone (including Singapore, Malaysia, Indonesia and Thailand territoties) developing international economic region could become one of the largest nuclei of the global economy.