ИСТИНА

The Erythrina and Lycorine type tetracyclic alkaloids constitute two vast classes of natural products. Members of these families display remarkable biological activities and a number of pharmacological effects including sedative, hypnotic, hypotensive, antiasthmatic, spasmolytic, antineoplastic, diuretic, CNS activity, etc. for Erythrina scaffold, as well as anticancer, acetylcholinesterase (AChE) inhibitory, antiviral, antibacterial, anticonvulsant and antidepressant activities, etc. for latter. An equal if not exciding interest is attracted to their challenging polycyclic cores as a plethora of synthetic approaches were designed over the past 50 years. Herein we will propose a new route to the synthesis of such scaffolds.