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Currently used membranes have an asymmetry of the porous structure only in the cross section (1D asymmetry: narrow pores in the selective layer and larger pores in the support layer). At the same time, the passage of the separated mixture along the filtration module based on membrane separation is usually accompanied by a significant change in its composition and physico-chemical properties. The problem of reducing the negative effect of concentration polarization effect in separation of real mixtures can be solved not only by using of turbulators, but also by developing membranes with transport characteristics that vary in terms of length and width, allowing to redistribute and control the rate of flow selection along the length of the membrane module. The production of such a membrane is possible by creating an anisotropic porous structure with the help of 3D printing.