ИСТИНА

Polymorphonuclear leukocytes neutrophils play a central role in the defense against microbial infections. In the immune response to bacterial and fungal infections neutrophils eliminate pathogens through phagocytosis. To effectively clear invading organisms, neutrophils must be capable of mounting rapid, vigorous responses to activating stimuli. Neutrophil exposure to pro-inflammatory lipids and cytokines, mitochondrial contents, and bacterial and viral products makes neutrophils more responsive to activating stimuli. Priming agents produce as pro- as well as anti-apoptotic activities. Inherent DNA immune activity was first discovered more than 30 years ago. However, effects of bacterial DNA and synthetic oligodeoxynucleotides (ODNs) on neutrophil cellular responses are not well characterized. The varying rates of neutrophil apoptosis may serve different functions in the inflammatory response. The presentation will cover our data on the effects of synthetic ODNs on apoptosis of human neutrophils. The results of our study revealed that distinct mechanisms used by ODNs to manipulate neutrophil lifespan. During phagocytosis neutrophils produce physiologically active compounds called leukotrienes. Neutrophil production of leukoriene B4 (LTB4) is responsible for a second wave of neutrophil recruitment during inflammation. In our study we compared the effects of ODNs of different structure on leukotriene synthesis in neutrophils during Salmonella bacteria phagocytosis. http://www.dnaday.com/2018/scientificprogram3-5.asp