ИСТИНА

Helminthiases are among the most dangerous parasitic diseases of humans, animals and plants, and therefore the development of effective anthelmintic drugs remains an urgent problem of modern science. Known methods for the treatment of animal helminthiases are based on the use of a wide range of anthelmintic drugs, many of which, due to their poor solubility, often do not provide the necessary efficacy. To achieve this result, it is necessary to use overestimated dosages of drugs, which, in turn, leads to an increase in the likelihood of undesirable side effects. To improve the solubility of anthelmintic drug substances, methods based on the formation of their intermolecular complexes with water-soluble synthetic and / or natural polymers are often used. Such an approach in many cases allows to achieve reduction of dosages of medicinal substances while maintaining therapeutic activity, as well as reducing their toxicity. We propose an innovative approach to the creation of effective benzimidazole anthelmintic preparations by mechanochemical modification of their substances with water-soluble polymers in ball mills with shock-abrading type of action. Our researches confirmed the possibility of solid-phase mechanochemical technology to increase the solubility of poorly soluble substances of medicinal substances by their joint treatment with water-soluble polymers in energy-controlled activators. The resulting preparations have not only increased solubility, but also high activity with reduced doses of the preparation. In this case, the drugs exhibit an extended spectrum of activity, not inherent in the original substance.