ИСТИНА

The aim of this study was to evaluate the inheritance of 2D:4D ratio traits in a large sample of ethnically homogeneous pedigrees. Familial correlations and heritability analysis in a sample of 1,541 subjects (803 men and 738 women, mean age of 47.78±16.89, range 18-90 years), were evaluated. Familial correlations of 2D:4D ratio traits showed no significant correlation for spouses, however, parent-offspring (0.15-0.28, p<0.001) and sibling correlations (0.13-0.38, p<0.009) were found significant. Heritability (H2) of visual classification of 2D:4D ratio was 0.36 for the left and 0.28 for the right hand); finger ratio was 0.55 and 0.66, respectively; the ray ratio was 0.49 and 0.59, respectively, indicating the existence of a clear familial aggregation of 2D:4D ratio variation in the Chuvashian pedigrees, which cannot be explained by common environmental effects. Results of our study suggest the familial aggregations of finger ratio variation (for all traits) in Chuvashian pedigrees.