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Functionalized organophosphorus acids and their derivatives with aryl and bicyclic moieties are widely used in organic synthesis and may be considered as promising biologically active compounds and efficient ligands. We proposed the convenient synthesis of new these acids using trimethylsilyl esters of trivalent organophosphorus acids containing highly reactive PH and POSi moieties and starting indene, aldehydes or ketones with aryl and bicyclic moieties. Thus a number of functionalized compounds 1-7 as structural organophosphorus biomimetics of important hydroxy or amino acids are synthesized by us. Also trimethylsilyl-containing organophosphorus compounds easily react with methanol excess or sodium methylate in methanol giving water soluble acids or their sodium salts in high yields. The resulting compounds are the perspective precursors for multitarget drug discovery.