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9-{2-[(Phosphonomethyl)oximino]ethyl}adenine – acyclic phosphonate analogue with broad antiviral activityдоклад на конференции
- Авторы: Pavel Solyev, Marina Kukhanova, Maxim Yasko
- Международная Конференция (Конгресс) : FEBS Congress 2013 "Mechanisms in Biology". July 6 - 11, 2013. Saint-Petersburg, Russia
- Даты проведения конференции: 6-11 июля 2013
- Дата доклада: 8 июля 2013
- Тип доклада: Стендовый
- Докладчик: не указан
- Место проведения: Saint-Petersburg, Russia
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Аннотация доклада:
In our recent study we have synthesized new acyclic nucleotide analogues with broad antiviral activity: E- and Z- 9-{2-[(phosphonomethyl)oximino]ethyl}adenine containing oxime fragment in the chain. During this synthesis some findings for aminooxycompounds that allowed us to obtain overall yield of 75% were discovered. The final Z and E isomers demonstrated anti-HIV and anti-herpetic activity as well as inhibited a full-length hepatitis C virus replicon.
- Добавил в систему: Сольев Павел Николаевич