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Near-infrared fluorescent probe for detecting NF-kB activation in a mouse model of type 1 diabetesдоклад на конференции
- Авторы: Taghian T., Bogdanov A., Zhang S., Melelev V.
- Международная Конференция : 13th annual ESMI 2018, San-Sebastian, Spain 8
- Даты проведения конференции: 20-23 марта 2018
- Дата доклада: 21 марта 2018
- Тип доклада: Устный
- Докладчик: Bogdanov A.
- Место проведения: San-Sebastian, Spain
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Аннотация доклада:
Results of biochemical (EMSA) and fluorescence microscopy studies showed that NIR-ODN imaging probe was specific for NF-kB both in cell cytoplasm and nuclei of pancreatic cells. The binding to nuclei and cytoplasmic fraction of pancreatic islet cells correlated with the increased NF-kB activity/expression after MLD-STZ treatment damage to the pancreas. The tested NIR probe is not species-specific and can be used in studies of various animal models of diabetes as well as other inflammatory disease.
- Добавил в систему: Метелев Валерий Георгиевич