ИСТИНА

Hypoxia is a common neonatal stress that leads to long-lasting complications. Neonatal hypoxia can be chronic or acute and may differ in exposure time but eventually it results in CNS trauma due to oxidative stress which is a consequence of an alteration in the equilibrium of the production of reactive oxygen species (ROS) and antioxidative processes. Therefore, the detoxication of ROS is an essential task within the brain. The tripeptide glutathione is the major antioxidant for reducing free radicals in the body and presents in high concentrations in cells of all organs. Reduced form of glutathione (GSH) interacts with ROS in reaction of detoxification and becomes oxidized (GSSG). Within the cell GSH regenerated from GSSG by enzyme glutathione reductase. Oxidized glutathione content is much lower than reduced, and the ratio of reduced glutathione to oxidized glutathione (GSH/GSSG) within cells is an indicator of oxidative stress.