ИСТИНА

One of the most commonly exploited strategies in anticancer treatment is based on the use of DNA-damaging agents which trigger apoptotic death of cancer cells. However, these widely used drugs have significant toxic effects on normal cells, which also undergo apoptosis upon treatment. Thus, development of approaches that increase therapeutic effects of anticancer drugs is an important task of oncomedicine. The combination of calorie restriction (CR) and the chemotherapeutic drugs has been shown to enhance programmed death of cancer cells that will allow decreasing the dose of chemotherapy drugs and reducing their toxic effects. In thus study we examined the mechanisms how serum deprivation, which serves as an in vitro model of CR, modulates apoptosis in two cancer cell lines (ovarian carcinoma line Caov-4 and cervical adenocarcinoma line HeLa) in response to treatment with DNA-damaging agent cisplatin.