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Interactions of laser radiation with gas cluster targets have been investigated in the past two decades. Cluster jet, obtained by the adiabatic condensation of gas flow, has pronounced nonlinear optical properties and com-bines the advantages of solid-state and gas target. Cluster inherits high local density and this implies high value of nonlinear response. At the same time cluster beams are not exposed to ablation and renew their properties before each act of interaction with the laser pulse. There were observed and predicted various nonlinear effects during interaction of intense laser pulses with cluster jets: gener-ation of X-ray radiation, generation of optical harmonics, self-focusing, Stimulated Raman Scattering. It was shown theoretically and experimentally that absorption of laser radiation in cluster beam can reach high value (up to 95%) which is related to linear (Mie) and nonlinear reso-nance interactions. Resonance absorption of pulse energy results in efficient production of X-Ray and fast charged particles. In this way, further studies of interaction of intense laser pulses with clusters seems reasonable due to the possibility of usage in various practical applications and solving fundamental problems of behavior of matter under intense laser fields.