ИСТИНА

In KM stain rats audiogenic fit intensity and postictal catalepsy expressivity are maximal. These data permit to propose KM strain rats as a genetic model of (postictal) catalepsy. In intact KM, «0» and «4» rats the duration and expressivity of the post-ictal catalepsy correlated with audiogenic fit intensity. In Long-Evans-selected and Wag/Rji rats this correlation is weak or absent. Sound exposition, which is not accompanied by audiogenic seizures, leads to significant decrease in pain threshold, while audiogenic seizures are accompanied by period of absolute analgesia. In rat genotypes, which were selected for audiogenic seizures independently (KM and Long-Evans selection), the negative correlation between seizure intensity and anxiety level was revealed. The density of D2-dopaminergic and NMDA-glutamate receptors in the striatum of KM strain rats are significantly lower compared to rats of control “0” strain (not predisposed to audiogenic seizures). Levetiracetam and caffeine alter audiogenic fit and postictal catalepsy indices in parallel, while dizocilpine, phenotropyl, phenozepam and corazole cause the dissociation of their indices. KM rats express maximal intensity of catalepsies (spontaneous, postictal, pinch-induced and haloperidol-caused). The effects of these states reveal the features of additivity. Pinch-induced catalepsy in absence of sound exposition was noticed in adult KM, “0” and “4” strain rats (genetic groups with KM genetic background), while other genetic groups did not develop this state. The pinch-induced catalepsy increased in all groups after audiogenic seizures. The exception is the “0” rat strain which develops pinch induced catalepsy, with no audiogenic seizures! Data on KM rats showed that the dopaminergic system is the crucial one for developing postictal catalepsy with modulating influence of GABA-benzodizepine and NMDA- glutamate systems.