ИСТИНА

Fast development of laser technologies, in particular, optical measurement techniques allow for assessing the optically measured characteristics of biological tissues and cells in norm and pathology. Diabetes mellitus (DM) is a metabolic disease characterized by high blood sugar levels over a prolonged period and alterations of vitally important systems of the human organism including the cardiovascular system. It is obvious that controling the rheological parameters under DM is very important. The rheological parameters are mostly related to the aggregation properties of red blood cells (RBCs), which are impaired in case of DM. Spontaneous aggregation of RBCs is the process leading to the formation of linear and 3D complex structures. The aggregation process significantly affects the blood viscosity and leads to the alteration of the blood circulation. This work focuses on the aggregation parameters of the RBC that characterize the time and velocity of RBC aggregates formation and can be measured in-vitro by laser systems. The techniques to be discussed are laser scattering aggregometry of RBC and cells trapping and manipulation with laser tweezers.