ИСТИНА

Various areas of polyconjugated systems application in medicine and biology are described. The relationship between the patterns of formation of chains containing a system of conjugated bonds with their properties, including biocompatibility, has been established. Questions of the kinetics and mechanism of oxidative polymerization, as well as theoretical approaches to calculating the molecular masses of polyaniline derivatives are considered. It is shown that the oxidative polymerization of aromatic amines is accompanied by frontal initiation, which is a consequence of the autocatalysis effect. The regularities of the interfacial polymerization of aniline and pyrrole at the solid/liquid interface are described, and the rate limitation of this reaction by monomer diffusion is proved. The possibilities of using composite materials and nanomaterials based on polyaniline and polypyrrole in imparting hemocompatibility to surfaces, as well as for delivery of biologically active substances, are shown. The prospects for increasing the response of nitrogen-containing electrically conductive polymers to various stimuli are discussed. In connection with the growing interest in the pathologies of the metabolism of dopamine derivatives, the kinetic regularities of its oxidation by ammonium peroxodisulfate have been established and the first general order of this reaction has been shown. An approach to immobilization of dopamine on a copolymer of N-vinylpyrrolidone and allyl glycidyl ether has been developed, which makes it possible to form hydrogels in the presence of oxidants and transition metal ions. The resulting hydrogels were pH sensitive and degradable in aqueous media. In connection with the reversibility of the oxidative cross-linking of dopamine immobilization products in the presence of sodium periodate, assumptions have been made about the mechanism of dopamine oxidative polymerization