ИСТИНА

2-cyanoacrylic acid esters are widely used to obtain polycyanoacrylate nanocapsules that are used as drug carriers. Its popularity is explained by ability to polymerize in an aqueous medium by the anionic mechanism without radical initiators giving biodegradable polymers. The study presents methods for preparation of nanocapsules with a partially crosslinked shell formed by surface active 2-cyanoacrylate monomers that are esters and adducts of 2-cyanoacrylic acid containing aliphatic and aromatic fatty moieties. This approach makes it possible to obtain nanoscaled carriers with sizes in the range from 20 to 200 nm. The introduction of two fatty substituents into the structure of the monomer allows to control the surfactant properties and obtain monomolecular Langmuir layers of high stability. The synthesis of 2-cyanoacrylate capsules is carried out in aqueous media and avoids the use of organic solvents, capsules are easily resuspended after lyophilization and do not exchange contents with each other and the environment. Capsules are suitable for clinical use. It’s capable of biodegradation and excretion from the body, as well as the absence of toxicity of cyanoacrylates have been approved for medical application as components of surgical adhesive compositions. Thus, a method has been developed for the synthesis of surface active esters of 2-cyanoacrylic acid and adducts at the double bond of 2-cyanoacrylates, as well as methods for obtaining a wide range of hollow nanoparticle for drug delivery