ИСТИНА

in restorative surgery. For example, in the case of reconstructive osteoplasty in the first period after the operation, the release of wound healing active is required, however for a longer period local release of morphogenetic proteins is necessary. The work studies approaches to the creation of biodegradable materials capable of releasing several active substances into the bloodstream, each with its own, independent release kinetics. The approach was studied using biodegradable foamy protein-polycyancarylate composite material applied for bone tissue substitution. It comprises porous poly-2-cyanoacrylate scaffold containing, collagen, bone morphogenetic protein (BMP) and insulin as wound healing stimulator. This combination of biologically active substances allows for local growth and differentiation of bone tissue osteoblasts, ensuring gradual substitution of the biodegradable implant with its own bone tissue. To ensure the independent release of drugs into the bloodstream, a combination of chemical methods of covalent binding of drugs to the scaffold material and physical encapsulation in polyethylene cyanoacrylate capsules with a permeable porous wall have been used. The rate of biodegradation was controlled by the addition of fluorinated hydrophobic cyanoacrylates. The efficacy was confirmed by in vitro experiments using tooth tissue cell cultures, as well as in vivo experiments on the model of bone union of the critical anastomosis of the rat tibia.