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Introduction: It is known that physical health is related to emotional state. At the same time, the socio-cultural mediation between the subjective assessment of physical health and emotional state at the level of different countries as well as the level of different regions of one country requires further study. Objectives: Identification of the relationship of subjective assessments of physical health and emotional state in residents of different regions of Russia. Methods: Respondents were 210 men and 403 women aged 14 to 76 years (M=26.9; SD=13.7) from 6 regions of Russia. They were asked to describe as a whole (1) the state of their physical health and (2) their emotional state at the present time, by selecting in both cases one of the answer options: “excellent” “good”, “average”, “bad”, “very bad”. Results: As the values of the Spearman correlation coefficient showed, subjective assessments of physical health and emotional state were significantly related throughout the sample (r=0.507; p<0.001), separately for men (r=0.516; p<0.001), and for women (r=0.489; p<0.001). This correlation was found for each region, but to a different extent: Moscow (r=0.345; p<0.001), St.-Petersburg (r=0.443; p=0.003), Udmurtia (r=0.482; p<0.001), Sakha (r=0.491; p<0.001), Sverdlovsk region (r=0.632; p<0.001), Kemerovo region (r=0.347; p=0.001). Conclusions: There was a significant correlation between subjective assessments of physical health and emotional state in both men and women. The correlation is typical for the sample as a whole, but its strength differs in each of the studied regions of Russia. The research was supported by the Russian Foundation for Basic Research, with the Grant 17-29-02506. Conflict of interest: No Keywords: health; emotional state; subjective assessment; sociocultural determination