ИСТИНА

The pandemic situation with COVID-19 - new coronavirus infection due to SARS-CoV-2, requires an integrated approach, including the creation of vaccines to prevent the spread of the disease, the development of new drugs aimed at lowering the viral load, suppressing of an excessive immune response, preventing the pulmonary fibrosis and the disseminated intravascular coagulation. The development of new prognostic algorithms for differential diagnostics to predict and reduce the severity and complications of COVID-19 remains extremely relevant. It should be noted that the severe course of the disease has been registered not only in elderly patients or patients suffering from comorbidities but also in healthy young people. One of the promising targets for studying COVID-19 complications such as pneumonia, systemic inflammation and disseminated intravascular coagulation is the hemostasis system. We conducted a comprehensive study using blood serum from patients (N = 60) with confirmed COVID-19 admitted to N.V. Sklifosovsky Research Institute for Emergency Medicine, Moscow, within the last 4 months (from April to July 2020). The levels of plasminogen (Plg), plasminogen activator inhibitor 1 PAI, IL-1a, -17, TGFb, TNFa, and adiponectin in blood serum were correlated with apoptotic markers in blood leukocytes (AKT, BAD, BCL-2, CASPASE-8, -9, JNK and P53), with CT lung scans, BMI, duration of mechanical ventilation and mortality. Our preliminary data show a consistent relationship between apoptosis of blood cells, BMI and mortality.