ИСТИНА

Calcium pyrophosphate Ca2P2O7 can be used for obtaining porous matrix in regenerative methods for treating bone defects, as a carrier of drugs and for the cultivation of bone cells. To obtain a porous matrix with a given geometry of the pore space, the method of extrusion layer-by-layer 3D printing from highly concentrated suspensions can be used. The preservation of the form and the formation of brushite or monetite as direct precursors of the pyrophosphate phase is achieved due to the chemical reaction. The aim of this work was to study the rheological properties of highly concentrated hardening suspensions (HCHS) containing calcium citrate, calcium oxalate and monocalcium phosphate monohydrate and to obtain biocompatible ceramic materials based on them. The resulting ceramic materials can be recommended for the manufacture of resorbable bone implants for the treatment of bone defects. Acknowledgement: This work was supported by the RFBR, grant nos. 18-29-11079, 20-03-00550.