ИСТИНА

Purpose: The aim of this study was to analyze the changes of the apparent diffusion coefficient (ADC) and contrast enhancement during neoadjuvant chemotherapy (NAC) for prediction of breast cancer response. Material and methods: 45 patients (55±10 y.o.) with pathologically proven breast cancer T2-T4 stages (TNM) underwent NAC followed by surgery were retrospectively enrolled. MRI was performed with 3T MR system before NAC, after 2rd and 4-6th NAC cycles including dynamic contrast-enhancement sequences and DWI. ADC value (mean of three tumor ROI), types of enhancement curves, percentage of wash-in and the largest tumor size were analyzed. The patients had 2-5 grades of pathologic response based on the Miller-Payne system. Conclusion: Contrast-enhanced MRI and DWI showed significant changes after NAC. The more aggressive tumors are known to have a better response to chemo- therapy, and that would minimize the possibility of a false-negative diagnosis made at MR imaging. This results could be used as imaging biomarkers to predict and assess pathologic response of breast cancer tumors to chemotherapy.