ИСТИНА

Translation machinery is an attractive target for the treatment of various human diseases. Many small molecule inhibitors that specifically affect protein synthesis in eukaryotic cells are potent anticancer, antiviral, anti-inflammatory, antifungal or antiparasitic drugs [1]. However, despite their medical significance, there is no single resource combining data on eukaryotic translation inhibitors. Thus, we have created a manually curated, continuously updated database, EuPSIC (for Eukaryotic Protein Synthesis Inhibiting Compounds), containing information about small molecules targeting eukaryotic ribosomes, translation factors, aminoacyl-tRNA synthetases, and signaling pathways associated with translation. Compounds are classified according to their mechanisms of action, targets, binding sites, and organism specificity. EuPSIC is linked to the ChEMBL, PubChem, and CMap databases, provided with appropriate filters and an interactive diagram. It can be used as a handbook of translation inhibitors and as a data source for in silico approaches. The database is available at http://eupsic.belozersky.msu.ru and currently contains information on 429 inhibitors. This work was supported by the Interdisciplinary Scientific and Educational School of Moscow University «Molecular Technologies of the Living Systems and Synthetic Biology» and by the Russian Foundation for Basic Research (grant no. 19-34-51047 to S.E.D.) 1. A Quick Guide to Small-Molecule Inhibitors of Eukaryotic Protein Synthesis. Dmitriev SE, Vladimirov DO, Lashkevich KA. Biochemistry (Mosc). 2020, 85, 1389-1421.