ИСТИНА

Phospholipid-based nanocarriers of relevant interest as biodegradable, biologically inactive systems, with antiallergic, antigenic properties [1, 2]. In recent years, the technology of obtaining phospholipid delivery nanosystems (PTNS) with an extremely small diameter from soybean phosphatidylcholine has been developed in the V.N. Orekhovich Research Institute of Biomedical Chemistry. PTNS are produced as a lyophilized powder, which is stable in time, while the incorporation of some drugs into PTNS sufficiently increases their bioavailability and therapeutic effectiveness [2]. Recently, soybean phospholipids, obtained as coproducts of soybean oil processing, stimulated the development of medicine (biomembrane bionics, liposomes, intracellular drug carriers, etc.) and chemical industry (aggregation and dispersion of nanomaterials, etc.) [3]. Although the full SAXS analysis by fitting the scattering curves is complicated because of a complex mixture of different components of soybean phospholipids, the methodology of contrast variation by using disaccharides (such as maltose) in the X-ray scattering experiment on small unilamellar vesicles (ULVs) opens up an opportunity to investigate the PTNS structure using the SAXS technique at synchrotron facilities [4]. On the basis of the SAXS data analysis and comparison of the DMPC and PTNS spectra, one can conclude that the phospholid transport nanosystem (PTNS) represents a vesicular system with the average radius of RPTNS = 160 ±2 Å, i.e. the average size of vesicles is about 320 Å. This first insight into the morphology of PTNS nanoparticles allows one to carry out more detailed synchrotron investigations of PTNS and the respective numerical analysis [5]. References [1] R.B. Gennis, Biomembranes, Molecular Structure and Function, Springer-Verlag (1989) [2] D. Lombardo, P. Calandra, D. Barreca, S. Magazù, M.A. Kiselev, Nanomaterials, 6 (7), 125 (2016). [3] D. Liu, F. Ma, Soybean phospholipids, D. Krezhova (Ed.), InTech pp. 483-500, (2011), [4] M.A. Kiselev, P. Lesieur, A.M. Kisselev, D. Lombardo, M. Killany, S. Lesieur, J. Alloys Compd., 328, 71 (2001). [5] Kiselev MA, Zemlyanaya EV, Ipatova OM, Gruzinov AY, Ermakova EV, Zabelin AV, Zhabitskaya EI, Druzhilovskaya OS, Aksenov VL. J Pharm Biomed Anal. 114, 288 (2015)