ИСТИНА

Enantioselective homogenous hydrogenation catalyzed by chiral transition metal complexes has become one of the most widespread methods for obtaining of optically active organic compounds, more commonly utilizing complexes based on Ru, Rh or Ir and including phosphorous-containing chiral ligands. Tetrahydro-1Н-benzodiazepinones represent a novel, currently developed class of bioactive compounds displaying antiasthmatic, antitumor, and neuroprotective activities. New bulky phosphite and phosphoramidite (L1 - L4) ligands were synthesized and tested in the asymmetric Rh-catalyzed hydrogenation of a series of substrates, including dimethyl itaconate, a- and b-dehydroamino acid derivatives and in the Ir-catalyzed hydrogenation of 2-methylindole. In Ir-catalyzed asymmetric hydrogenation of a series of 4-R-1,3-dihydro-2H-1,5-benzodiazepin-2-ones up to 74% ее was achieved. The structure of obtained compounds was determined based on one- and two-dimensional NMR spectroscopy data (1H, 13C, 31Р, 1H-1H COSY, 1H-1H ROESY, 1H-13C HSQC and 1H-13C HMBC).