ИСТИНА

Potential molecular biomarkers of brain plasticity were investigated in mice after fear conditioning training and in empathic fear response. Expression of Pdk4, Leo1 and Nfe2l, Gadd45G as well as classical marker of neuroplasticity c-Fos were analyzed by immunohistochemistry in mice primary cingulate cortex, structure known to be critical for fear learning and empathy. Density of Pdk4, Leo1 and Nfe2l1 immunopositive cells substantially elevated after fear conditioning compared to home cage group. It was shown that Nfe2l1 and c- Fos expression increased in structures associated with emotional empathy in mice.