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The aim of the work is to develop and characterize molecular systems based on cyclodextrins (CDs), polyethylenimines (PEIs) and mannose – carriers for targeted delivery to alveolar macrophages of drugs for the treatment of a wide range of diseases, including postcovid pneumonia and tuberculosis. Biopharmaceutical properties of drugs loaded into molecular containers can be improved: increased solubility and bioavailability, slowing release in tissues, protection from destruction, concentration of drugs in the target organ, tissues – due to the complexation of fluoroquinolones with cyclodextrin derivatives, as well as their copolymers.
№ | Имя | Описание | Имя файла | Размер | Добавлен |
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1. | Разрешение на публикацию | Development_-_thesises.jpeg | 219,9 КБ | 30 ноября 2022 [ZlotnikovID] | |
2. | Полный текст | BioNanoTox_-_theses_Zlotnikov_Kudryashova.docx | 15,6 КБ | 20 мая 2022 [ZlotnikovID] |