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Previously, the effective use of carbocyanine dyes for the visualization of "small molecules" by using non-covalent interactions was studied. We demonstrated the possibility of determining aminoglycosides using the strategy of enhancing the fluorescence of carbocyanines in surfactant solutions at premicellar concentrations [1, 2]. In continuation of these studies, a convenient method for monitoring the delivery of large hydrophilic molecules into cells based on the use of chitosan nanocontainers has been developed. A series of pentamethine carbocyanines containing hydrophobic substituents has been synthesized. Carbocyanine 1 turned out to be the most promising for solving this problem. Using this dye, a method for imaging-guided drug delivery to cells was developed and an approach was proposed for visualizing drug release in the organism.
№ | Имя | Описание | Имя файла | Размер | Добавлен |
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1. | Полный текст | тезисы | Doroshenko._6-j_Severo-kavkazskij_simp_op_org_him_2022.pdf | 406,1 КБ | 1 января 2023 [beklem] |
2. | Расписание конференции | NCOCS2022_schedule.pdf | 1,0 МБ | 25 мая 2022 [doroshenkoiran] | |
3. | Полный текст | Tezisyi_NCOCS2022_Doroshenko.pdf | 677,8 КБ | 25 мая 2022 [doroshenkoiran] |