ИСТИНА

Reductive amination plays a key role in pharmaceutical and medicinal chemistry owing to its synthetic merits and ubiquitous presence of amines among biologically active compounds. Nitrogen-containing compounds play an important role in different fields of chemistry. Various reducing agents for the reductive amination are known. The main problem of common reducing agents is a balance between activity and selectivity. For example, one of the most selective reagents, sodium triacetoxyborohydride, can reduce starting carbonyl compounds to alcohols, thus lowering the yield of the target amines. Small numbers of functional groups are survivable using typical reducing agents. We developed new methods and upgraded known protocols for effective and selective reductive amination.