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Appendicular osteosarcoma is the most common bone tumor in dogs. Without receiving specific combined treatment, the majority of patients are euthanized within 16-20 weeks after initial diagnosis due to metastatic spread or intractable tumor-induced pain. Despite certain beneficial effects of amputation, the radical surgery might be contraindicated in giant dogs, patients with orthopedic and neurological disorders or with excessive weight. In these patients, in particular, limb-sparing surgical techniques allow to save functional activity of osteosarcoma-affected extremities and sufficiently improve patients’ quality of life. We analyzed overall survival, surgical results and recurrence rate in dogs with histologically diagnosed appendicular osteosarcoma after limb-salvage surgery using de-immunized allogenic bone grafts coated with recipient’s stromal mesenchymal cells. 25 dogs underwent a combined treatment with chemotherapy (cisplatin, 60-70 mg/m2, IV, 3-4 cycles) and wide segmental resection of the affected bone with an allograft defect replacement. Overall survival in the group amounted to 321 days, and median progression-free - 222 days. Local relapse was diagnosed in 4 cases (16,6%), of which 50% were recorded within 150 days and the rest – after the two-year period. The overall functional outcome in the group was good.The combined limb-sparing protocol is an efficient treatment option for canine appendicular osteosarcoma, wherein limb-salvage surgery might be preferable in certain groups of patients due to its beneficial potential to improve mobility and quality of life.