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The proposed approach allows comparing strategies of struggle against corruption in hierarchies of arbitrary topology. Mathematically the comparison problem adds up to a relevant system of a large number of ordinary differential equations, or to a partial differential equation, and to corresponding discrete models. The underlined “Power-Society” model allows computing the level of power of instances in the hierarchy, which determines potential opportunities for corruption along with the behavior model of bureaucrats. In our study we limit our consideration to comparing the effectiveness of corruption suppression in different levels of hierarchy (from the “costs-vs-gains” viewpoint). Generally we found that the most profitable strategy consists in suppressing the lowest bureaucrats. A possibility of integration of the proposed system-social and game theory approaches into the general model is demonstrated.