ИСТИНА

Nowadays target drug delivery system is the method for delivering physiologically active substances to the tar- get site of action or site of absorption. It allows increase the concentration of delivered substances in the targeted parts of the body and reduce side effects of the drug on healthy organs and tissues. Nanoparticles are one of the most promising types of drug delivery systems. The advantages of these nanocarriers are their ability to control drug release rate. In the work the polymer nanoparticle consists of two layers. The inner layer is formed by adduct of ethyl-2-cyanoacrylate and octyl alcohol and the outer polysaccharide layer was variable. All selected polymers are biocompatible, non-toxic and biodegradable. The main characteristics of such systems that affect their effec- tiveness are particle size and surface charge. Depending on the selected polysaccharide the formation of particles and their size were studied.