ИСТИНА

Organophosphorus nerve agents are one of the most dangerous chemical weapons and methylphosphonic acid is the most stable hydrolysis product of them. Methylphosphonic acid determination is a direct proof of chemical weapons application. Here we describe novel analytical approaches, developed in our laboratory, that allows to detrmine methylphosphonic acid in different matrices with use of reversed phase, anion-exchange and hydrophilic interaction liquid chromatography with tandem mass spectrometric detection. Every approach is charactiresed by good metrological characteristics and in most cases limits of detection are lower than those described in the literature.