ИСТИНА

Today, the growing resistance of various types of pathogenic fungi to antifungal drugs is a serious problem on a global scale. The problem of resistance can be solved through the use of photodynamic therapy (PDT), which is well known in oncological practice. The principle of action is based on irradiation with light of a given wavelength of photosensitizer (PS) selectively accumulating in pathological cells. Under the action of such irradiation, intracellular triplet oxygen in the presence of PS goes into reactive singlet state, which leads to irreversible consequences: membrane destruction and cell death.