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I-N phase transition depends on CNC aspect ratio and length distribution;- increase in ionic strength (0.3 3..10 mM) results in a decrease of a nematic phase content;- bacterial CNCs form nematic phases at lower concentrations, and are more susceptible to salt induced aggregation; the effect of different counterions is attributed to generation of a repulsive hydration force, which is higher for cations with higher hydration energy (e.g. Li+); an attractive force due to entropy driven interactions in the presence of quaternary ammonium cations results in a sharper decrease of a nematic phase content