ИСТИНА

To design a rat model of proliferative vitreoretinopathy (PVR) by intravitreal injection of dispase in different concentrations. Screening models of PVR for rats are currently not developed. Most of the works were carried out on rabbits whose eyes are very different from human. Typically, the animals are injected with one type of cells involved in formation of PVR. Such models are inappropriate for investigation of PVR initiation process. Our work is based on EM Frenzel`s et al. research (1998) carried out on rabbits. Dispasewas injected intravitreally, causing inflammation and disruption of the blood- barrier, followed by the development of PVR.