ИСТИНА

The replacement of the carboxyl group of amino acids with an acidic phosphorus-containing group gives rise to a big family of the compounds.This type of substances is sterically different and has ionization constants different from amino acids, including the pKa of the NH2-group. However, aminophosphonates are capable to interfere with amino acid metabolism both at the level of the isolated enzymes and at the organism’s level, and their action can be manifested at various stages of metabolism. Most studied are aminophosphonic acids (X= OH) and their derivatives (X= R’, OR’’, NHR’’’). The phosphorus-containing group is considered as a mimetic of the intermediate tetrahedral state of the carboxyl group and many aminophosphonates are effective inhibitors of the corresponding enzymes.Phosphonic (X=OH) and phosphinic (X=H) analogues of S-adenosylmethionine and S- adenosylhomocysteine were synthesized. The interaction of S-adenosylmethionine decarboxylase with AdoMet-PH and AdoMet-P and the interaction of phosphonic and phosphinic analogues of S-adenosylmethionine and S-adenosylhomocysteine with DNA methyltransferase Dnmt3a are discussed.