ИСТИНА

The origin of cancerous processes stems from a diverse range of mutations found in both somatic cells and germ lines. It is well known that promoter mutations in oncogenes play a significant role in the development and progression of cancer. Three G-quadruplexes (G4s) are formed in vitro from the hTERT gene promoter in a 96-nt DNA sample, even in the presence of single or double specific mutations in G-quadruplex (G4). G4 binds to the MutL component of the MMR repair system. This reduces the efficiency of repair of incorrectly paired bases compared to dsDNA. The study aims to test the hypothesis that the formation of G4 leads to an increase in the frequency of mutations in the neighborhoods of G4