ИСТИНА

Modern regenerative medicine has a great need in resorbable bioactive composite materials for bone implants. Biodegradable polymers, e.g. polylactide (PLA), filled with resorbable calcium phosphate (with the ratio Ca/P ≤ 1.5, e.g. tricalcium phosphate) are good candidates. Specific macroporous architecture for osteoconductivity enhancing can be achieved by 3D-printing process. In the case of 3D thermal extrusion technique it is necessary to produce composite filament (PLA/TCP) with uniform distribution of the phosphate particles inside PLA prior to printing and to develop printing regimes.